Colorectal Cancer Stage III Clinical Trials

11 recruitingLast updated: June 15, 2026

There are 11 actively recruiting colorectal cancer stage iii clinical trials across 17 countries. Studies span Early Phase 1, Not Applicable, Phase 2, Phase 3. Top locations include Barcelona, Spain, Madrid, Spain, Cincinnati, Ohio, United States. Updated daily from ClinicalTrials.gov.


Colorectal Cancer Stage III Trials at a Glance

11 actively recruiting trials for colorectal cancer stage iii are listed on ClinicalTrialsFinder across 6 cities in 17 countries. The largest study group is Early Phase 1 with 1 trial, with the heaviest enrollment activity in Barcelona, Madrid, and Cincinnati. Lead sponsors running colorectal cancer stage iii studies include City of Hope Medical Center, Biogenea Pharmaceuticals Ltd., and BioNTech SE.

Browse colorectal cancer stage iii trials by phase

Treatments under study

About Colorectal Cancer Stage III Clinical Trials

Looking for clinical trials for Colorectal Cancer Stage III? There are currently 11 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Colorectal Cancer Stage III trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Colorectal Cancer Stage III clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 111 of 11 trials

Recruiting

GUIDE.MRD-01-CRC: Clinical Validation and Benchmarking of Top Performing ctDNA Diagnostics - Colorectal Cancer

Liver Metastasis Colon CancerColorectal Cancer Stage III
Claus Lindbjerg Andersen590 enrolled15 locationsNCT06111105
Recruiting
Phase 2

A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer

Colorectal Cancer Stage IIIColorectal Cancer Stage II
BioNTech SE327 enrolled121 locationsNCT04486378
Recruiting
Phase 3

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

Colorectal Cancer Stage IIIColorectal Cancer Stage II
SWOG Cancer Research Network1,057 enrolled384 locationsNCT07018869
Recruiting
Not Applicable

Virtual Rehabilitation for Cancer Survivors

Breast Cancer Stage IBreast Cancer Stage IIBreast Cancer Stage III+9 more
University Health Network, Toronto388 enrolled1 locationNCT05898789
Recruiting

DANISH.MRD: Danish Assessment of Minimal Residual Disease by Liquid Biopsies

Colorectal, CancerColorectal NeoplasmsColorectal Adenocarcinoma+3 more
University of Aarhus1,600 enrolled10 locationsNCT06076811
Recruiting

Early Onset Colorectal Cancer Detection

Colorectal, CancerColorectal NeoplasmsColorectal Adenocarcinoma+5 more
City of Hope Medical Center400 enrolled13 locationsNCT06342401
Recruiting
Early Phase 1

COLONYVAQ™, a Quantum-Classical Guided Personalized Neoantigen Vaccine for MSS Stage III Colorectal Cancer

Colorectal Cancer MetastaticColorectal Cancer Stage IIIColorectal Cancer Stage IV
Biogenea Pharmaceuticals Ltd.12 enrolled1 locationNCT07328087
Recruiting

Splicing-based Predictive Learning for Individual Chemotherapy Evaluation in Colorectal Cancer

Colorectal, CancerColorectal Cancer RecurrentColorectal Cancer Stage III+1 more
City of Hope Medical Center200 enrolled1 locationNCT07226115
Recruiting

Stage II/III Colorectal Cancer Recurrence

Colorectal, CancerColorectal AdenocarcinomaColorectal Cancer Recurrent+2 more
City of Hope Medical Center400 enrolled4 locationsNCT06314958
Recruiting

Early Detection of Advanced Adenomas and Colorectal Cancer

Colorectal, CancerColorectal NeoplasmsColorectal Adenocarcinoma+15 more
City of Hope Medical Center2,000 enrolled6 locationsNCT06342440
Recruiting

A Translational Study for Locoregional Recurrence of T4 Colon Cancer

Colorectal Cancer Stage IIIT4 Colorectal CancerColorectal Cancer Stage II
National Taiwan University Hospital60 enrolled1 locationNCT06958926