RecruitingACTRN12605000571673

THE EFFECTS OF NUTRITIONAL SUPPORT OF CRITICALLY ILL PATIENTS REQUIRING MECHANICAL VENTILATION AS ASSESSED BY V/Q RATIO

THE EFFECTS OF NUTRITIONAL SUPPORT OF CRITICALLY ILL PATIENTS REQUIRING MECHANICAL VENTILATION


Sponsor

Intensive Care Unit, RMH

Enrollment

30 participants

Start Date

Jun 4, 2005

Study Type

Interventional

Conditions


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study is looking at how tube feeding affects the lungs of critically ill patients on breathing machines (mechanical ventilators) in intensive care. Specifically, researchers are measuring the ratio of air to blood flow in the lungs (V/Q ratio) to see whether the type or amount of tube feeding affects how well the lungs work. This could help improve nutritional care for ICU patients. You may be eligible if: - You are 18 years or older - You have been admitted to ICU with acute respiratory failure and need a breathing machine for more than 48 hours - You are receiving or about to start tube feeding through the stomach or small bowel - You or your next-of-kin have given consent to participate You may NOT be eligible if: - You have diabetes, kidney failure, or liver failure - You are receiving nutrition through a vein (total parenteral nutrition) - You are not expected to survive more than 24 hours, or are not receiving active medical treatment - You are under 18 years old - You have a condition that prevents tube feeding - You are already enrolled in another study that might affect the results Talk to your doctor about whether this trial might be right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Patients who agree to participate in the study and fulfil the inclusion criteria will be randomised to one of two treatment groups. 1.Standard therapy group will receive high-carbohydrate low-fat ent

Patients who agree to participate in the study and fulfil the inclusion criteria will be randomised to one of two treatment groups. 1.Standard therapy group will receive high-carbohydrate low-fat enteral feed (16.7% protein, 30% fat and 53.3% carbohydrates) at a target rate as decided by the treating physician and dietician for a maximum of 5 days following randomisation. 2.Alternative therapy group will receive high-fat low-carbohydrate enteral feed (16.7% protein, 55.2% fat and 28.1% carbohydrates) at a target rate as decided by the treating physician and dietician for a maximum of 5 days following randomisation. All patients will receive enteral feeding by continuous flow for 24hrs/day. The decision to commence or cease enteral feeding will remain with the treating physician. The measurement of VO2, VCO2, resting energy expenditure and respiratory quotient will be made on all participants 12 hourly for a maximum of 5 days using the indirect calorimeter. The indirect calorimeter is connected to the expiratory outlet of the ventilator, collecting and analyzing gas that is normally discharged into the atmosphere.


Locations(1)

Australia

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ACTRN12605000571673