RecruitingACTRN12609000336280

Basal-bolus insulin versus sliding scale insulin for managing blood sugar levels in hospitalized diabetic patients

Hospitalized diabetic patients undergoing basal-bolus insulin versus sliding scale management for control of blood glucose levels


Sponsor

Repatriation General Hospital

Enrollment

158 participants

Start Date

Feb 1, 2009

Study Type

Observational

Conditions

Summary

While basal-bolus insulin management is preferred over sliding scale for glycaemic control of hospitalised diabetics requiring intensified glycaemic control, there are no recommended basal-bolus approaches, and little data comparing the 2 approaches. The development of our basal-bolus approach requires testing to ensure its clinical efficacy, and that it is actually a better practice than sliding scale insulin. The main comparator will be the mean daily glucose readings taken from the routine four times daily capillary blood glucose measurements.


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study is comparing two methods of managing blood sugar in diabetic patients who are in hospital and need their insulin adjusted. One method uses a fixed schedule of insulin doses (basal-bolus); the other uses a sliding scale that adjusts insulin based on current blood sugar readings. The study wants to find out which approach keeps blood sugar better controlled during a hospital stay. You may be eligible if: - You are 18 years or older - You have diabetes - You have been admitted to hospital and need intensified blood sugar management with insulin You may NOT be eligible if: - There are no specific exclusion criteria listed for this study Talk to your doctor about whether this trial might be right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Basal-bolus insulin management via subcuteous injection is now recommended for inpatient glycaemic control. This replaces the old subcutaneous injection sliding scale insulin management approach. This

Basal-bolus insulin management via subcuteous injection is now recommended for inpatient glycaemic control. This replaces the old subcutaneous injection sliding scale insulin management approach. This study will prospectively collect performance data around a basal-bolus insulin approach developed at this hospital and compare it to retrospective data around the use of sliding scale insulin management at the hospital. Four times daily capillary blood glucose will be recorded in each group. Subcutaneous sliding scale insulin is initiated at the doctors discretion and the quantitative adjustment within the sliding scale is empirical, depending on what insulin doses the doctor feels are appropriate for that particular patient. Frequency of insuin administration is generally four times daily but may vary. This is continued until either discharge or the treating doctor feels the patient will maintain satisfactory glycaemic control without sliding scale insulin intervention, with a maximum data collection of 1 week. This data will be collected retrospectively as the hospital has now switched over to a basal-bolus insulin management approach. The basal-bolus insulin management (via subcutaneous injection) is intiated at the discretion of the treating doctor. An initial daily insulin dose is calculated according to set criteria, and 50% of this is then divided into a basal (glargine) dose administered once daily and 50% to rapid-acting insulin split into bolus doses three times daily prior to each meal +/- a small dose of correctional insulin depending on the blood glucose level at the time. This is continued until either discharge or the treating doctor feels the patient will maintain satisfactory glycaemic control without basal-bolus insulin intervention, with a maximum data collection of 1 week.


Locations(1)

Australia

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ACTRN12609000336280