RecruitingACTRN12611000067976

The acute effects of coffee extract on cognitive function and mood in healthy older adults

Sponsor

Nestec

Enrollment

60 participants

Start Date

Nov 1, 2010

Study Type

Interventional

Conditions

Cognitive Function Cerebral Blood Flow

Summary

Participants come for one practice visit where they go through the screening questions and provide informed consent. They also practice on all cognitive and mood tasks they will be doing on their subsequent testing sessions. Participants come for 3 testing sessions at least 1 week apart. At each testing session, they first complete baseline 'mood, cognitive, mood' assessments and doppler ultrasound followed by treatment administration. They complete 'mood, cognitive mood' assessment at 40mins and 120mins post dose and doppler at 90mins post dose

Eligibility

Sex: Both males and femalesMin Age: 50 YearssMax Age: 100 Yearss

Inclusion Criteria1

Age 50 and over

Exclusion Criteria16

Light to moderate coffee drinkers (i.e. with caffeine)
Drink no more than 8 cups of coffee per week
Participants must abstain from caffeine-containing foods/beverages and alcohol for 24 hours prior to the training session and each testing session.
Written informed consent obtained
Existing or pre-existing physical or neurological conditions
History of psychiatric, cardiac, endocrine, gastrointestinal, or bleeding disorders
Clinically high blood pressure
Under treatment with spironolactone-like anti-diuretics, aldosteron-receptors antagonists or angiotensin II- antagonists
Hearing impairment
Psychoactive medications
History of substance abuse
Smoker
Food allergies
Potassium reduced diet
Score <24 on the Mini-Mental State Exam
Currently participating or having participated in another clinical trial during the last 2 months prior to the beginning of this study

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Interventions

Participants each consume one dose of each of the 3 treatments: coffee (6g), coffee extract (540mg), placebo at least 1 week apart. All treatments are powder form and mixed with water (with milk/sacc

Participants each consume one dose of each of the 3 treatments: coffee (6g), coffee extract (540mg), placebo at least 1 week apart. All treatments are powder form and mixed with water (with milk/saccharin as desired)