The acute effects of coffee extract on cognitive function and mood in healthy older adults

This study is looking at whether a concentrated coffee extract affects memory, attention, mood, and blood flow to the brain in healthy older adults. Participants visit the research site on three separate occasions, each at least a week apart, and receive different doses of the coffee extract or a placebo (inactive drink) in a random order. Researchers measure how well participants think and feel before the drink and again at 40 minutes and 2 hours after taking it. You may be eligible if: - You are 50 years of age or older - You are generally healthy - You drink coffee (with caffeine) but no more than 8 cups per week - You are willing to avoid all caffeine-containing foods and drinks and alcohol for 24 hours before each study visit You may NOT be eligible if: - You have a known physical or neurological health condition - You have a history of psychiatric, heart, hormone, digestive, or bleeding disorders - You have high blood pressure - You are taking certain blood pressure medications (spironolactone-like drugs, aldosterone receptor antagonists, or angiotensin II antagonists) - You have hearing problems - You take psychiatric medications - You have a history of substance abuse - You currently smoke - You have food allergies - You are on a low-potassium diet - Your score on a cognitive test (Mini-Mental State Exam) is below 24 out of 30 - You have been in another clinical trial in the past 2 months Talk to your doctor about whether this trial might be right for you.