RecruitingACTRN12613000126718

The anaesthesia pre-oxygenation trial - using O2 Flush and Nasal oxygen for pre-oxygenation compared to traditional methods.

The effect of anaesthesia pre-oxygenation with O2 flush and nasal prongs on end tidal O2 in healthy adult volunteers


Sponsor

King Edward Memorial Hospital

Enrollment

24 participants

Start Date

Jan 10, 2013

Study Type

Interventional

Conditions

Summary

Prior to general anaesthesia the standard of care is to pre-oxygenation all patients. This involves the patient breathing 100% oxygen via a face mask. The 3 most common methods of pre oxygenation involve 4 deep breaths over 30 seconds, 8 deep breaths over 60 seconds or 3 minutes of tidal volume breathing (normal breathing) using high flow 100% oxygen (15L per minute via the anaesthesia machine with a face mask). The most common reasons for poor preoxygenation is an inadequate face mask seal resulting in the patient breathing room air (low oxygen content) through the leak. Nasal oxygen and the anaesthesia machine oxygen flush delivery higher flow rates than the standard method by the the anaesthesia machine so may reduce the amount of inspired air from the leak. Study Hypothesis - High flow oxygen with nasal oxygen or anaesthesia machine oxygen flush produces higher end tidal oxygen levels (better pre oxygenation) in the simulated mask leak scenario.


Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 65 Yearss

Plain Language Summary

Simplified for easier understanding

Before any surgery requiring general anaesthesia, doctors give patients extra oxygen through a face mask — this is called pre-oxygenation. It fills the body's oxygen reserves before anaesthesia begins. This study is testing whether newer, higher-flow methods of delivering oxygen (using nasal tubes or the anaesthesia machine's flush setting) work better than the standard method, especially when the mask does not fit perfectly and air leaks in. You may be eligible if: - You are a healthy volunteer aged 18 to 65 years You may NOT be eligible if: - You have refused or withdrawn consent - You are currently pregnant Talk to your doctor about whether this trial might be right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Each participants will perform repeated pre oxygenation in a computer generated randomised fashion. With a good mask seal 1. Standard - Anaesthesia machine (15L/min) 2. Standard PLUS nasal prong

Each participants will perform repeated pre oxygenation in a computer generated randomised fashion. With a good mask seal 1. Standard - Anaesthesia machine (15L/min) 2. Standard PLUS nasal prong oxygenation 3. Standard PLUS anaesthesia machine oxygen flush With simulated face mask leak 4. Standard 5. Standard PLUS nasal prong oxygenation 6. Standard PLUS anaesthesia machine oxygen flush Each of these interventions will be assess using deep breathing for 90 seconds and tidal breathing for 3 minutes. The wash out period will be a minimum of 3 minutes and until the end tidal O2 is less than 20%


Locations(1)

King Edward Memorial Hospital - Subiaco

WA, Australia

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ACTRN12613000126718