RecruitingACTRN12613000836730

Albuterol for Acute Lung Injury

lung recruitment maneuver with and without nebulized albuterol for acute lung injury, randomized controlled study

Sponsor

south valley university

Enrollment

50 participants

Start Date

Jul 20, 2013

Study Type

Interventional

Conditions

we will study the effect of adding aerosolized albuterol to lung recruitment maneuver during the managment of ALI due to surgical and non-surgical causes e.g acute lung injury following aspiration pneumonia , abdominal sepsis, pancreatitis, chest trauma , lobectomy,and so on

Summary

the study will test the value of adding aerosolized albuterol to lung recruitment during mechanical ventilation of patients with ALI to improve alveolar fluid clearance and oxygenation

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 60 Yearss

Plain Language Summary

Simplified for easier understanding

This study tests whether adding an inhaled medication called albuterol (a bronchodilator commonly used for asthma) can help patients with acute lung injury breathe better while they are on a breathing machine (mechanical ventilator). Acute lung injury means the lungs are not working properly due to illness or injury. Researchers hope the combination of albuterol and a special breathing technique called lung recruitment can help clear fluid from the air sacs in the lungs and improve oxygen levels. You may be eligible if: - You are between 18 and 60 years old - You have acute lung injury caused by a surgical or non-surgical condition - You are male or female You may NOT be eligible if: - You have an unstable blood pressure (hemodynamic instability) - You are currently taking beta-blocker medications Talk to your doctor about whether this trial might be right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

we will test the value of adding aerosolized albuterol sulphate 5mg dissolved in 10 ml sterile saline and nebulised by connecting the nebulizer to the endotracheal tube during mechanical ventilation

we will test the value of adding aerosolized albuterol sulphate 5mg dissolved in 10 ml sterile saline and nebulised by connecting the nebulizer to the endotracheal tube during mechanical ventilation of patients with acute lung injury (ALI) together with lung recruitment maneuver which is done in the form of increasing the positive end expiratory pressure (PEEP) 10 cm H2O above the lower infliction point for 15 minutes or 10 cmH2O above the pre-recruitment PEEP to be repeated every four hours for five to seven successive days in a trial to improve alveolar fluid clearance and improve oxygenation in these patients

Locations(1)

Qena, Egypt

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ACTRN12613000836730