RecruitingNCT00280202

Detection of Genetic Markers of Lung Cancer

Detection of Genetic Markers of Lung Cancer Initiation and Progression

Sponsor

University of Pittsburgh

Enrollment

6,000 participants

Start Date

Jun 1, 1996

Study Type

OBSERVATIONAL

Conditions

Lung Cancer

Summary

The purpose of this research study is to determine the genetic changes and immunologic changes that are involved in the development and progression of bronchogenic lung cancer.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Histologic confirmation of lung cancer, lung metastases from a primary site other than lung, mesothelioma or a radiographic lesion highly suspicious for malignancy
Written informed consent.
To be scheduled for a biopsy or surgical resection or have already had a biopsy and/or surgical removal of a lung mass

Exclusion Criteria1

None

Interventions

PROCEDUREBiopsy of the major carinal area

Biopsy performed intraoperatively

PROCEDUREBiopsy of abnormal & suspicious areas of the bronchial tree

Biopsy performed intraoperatively

PROCEDUREEvaluation of the tumor for DNA mutations

Tumor tissue is banked for future analysis.

PROCEDUREBronchoalveolar Lavage (BAL) for cytokine analysis

BAL performed intraoperatively

PROCEDURECorrelation of flow cytometric & RT PCR for TNM stage

Tissues banked for future correlative studies

PROCEDUREAnalysis of lymph nodes

Tissues banked for future analysis

Locations(1)

Hillman Cancer Center

Pittsburgh, Pennsylvania, United States

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