PTGS1 Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn

This study is investigating whether variations in the PTGS1 gene (which affects how the body processes certain hormones and fats) are linked to an increased risk of developing persistent pulmonary hypertension in newborns — a serious condition where blood pressure in the lungs is dangerously high after birth. **You may be eligible if...** - Your newborn has been diagnosed with persistent pulmonary hypertension of the newborn (PPHN) - You are willing to provide a blood sample from your baby for genetic testing - You or another parent/guardian can provide informed consent **You may NOT be eligible if...** - Your baby's high lung blood pressure is caused by a known structural heart defect rather than PPHN - You are unable or unwilling to provide informed consent - Your baby's condition is too unstable to allow for safe sample collection Talk to your doctor to see if this trial is right for you.