Postoperative or Salvage Radiotherapy (RT) for Node Negative Prostate Cancer Following Radical Prostatectomy

This study is examining whether radiation therapy given after prostate removal surgery (either immediately after or as a salvage treatment if PSA rises) affects long-term outcomes, focusing on side effects and quality of life in men with node-negative prostate cancer. **You may be eligible if...** - You had your prostate removed (open, laparoscopic, or robotic surgery) as primary treatment for prostate cancer - Your pre-surgery PSA was 20 ng/mL or lower **You may NOT be eligible if...** - Your cancer has spread to distant sites (metastasis) - You have previously received chemotherapy for any reason - You have had prior pelvic radiation that would interfere with the planned treatment - You have active inflammatory bowel disease affecting the rectum - You have had a hip replacement - You have another active cancer (except non-melanoma skin cancer) within the last 5 years - You are taking Saw Palmetto or methotrexate and unwilling to stop during radiation Talk to your doctor to see if this trial is right for you.