RecruitingNCT01099982

Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease

Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease, Effects of Mechanical Unloading on Myocardial Function and Structure in Humans

Sponsor

University of Utah

Enrollment

300 participants

Start Date

Sep 1, 2008

Study Type

OBSERVATIONAL

Conditions

Congestive Heart Failure

Summary

Hypothesis: Tissue and serum samples collected from end-stage heart failure patients receiving left ventricular assist device implantation (LVAD) or heart transplantation will provide information regarding the basic science of heart disease. Tissue and serum samples collected from a limited numbers of "healthy controls" (donor grafts that were not utilized for heart transplantation) will serve as a comparator in research database projects. Design: This is a registry project; there are no investigational treatments, drug or procedures associated with participation in registry activities. This project is an organized functional data and tissue data gathering and storing (database) endeavor with specific focus on the functional, structural, and molecular aspects of heart failure. Data collection will not immediately influence the course of treatment for any patient.

Eligibility

Min Age: 13 Years

Plain Language Summary

Simplified for easier understanding

This study collects heart tissue and blood samples from patients with severe heart failure who are undergoing heart surgery (either a heart transplant or implantation of a mechanical heart pump called an LVAD) to understand how heart disease changes heart tissue. **You may be eligible if...** - You are over 18 years old and have been diagnosed with heart failure and are scheduled for a heart transplant or LVAD surgery - OR you are a teenager (13-18) with heart failure who is large enough to receive an LVAD **You may NOT be eligible if...** - Neither you nor your representative speaks English - You or your representative is unwilling to provide written consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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