RecruitingNot ApplicableNCT02351141

Structure and Function MRI of Asthma

Sponsor

Dr. Grace Parraga

Enrollment

200 participants

Start Date

Jan 1, 2015

Study Type

INTERVENTIONAL

Conditions

Asthma

Summary

The investigators will apply 129Xenon and/or 3He image acquisition and analysis methods in 200 asthma patient volunteers in order to characterize and probe the relationship between lung structure and function using imaging.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This trial is using special lung MRI scans to study how asthma changes the structure and function of the airways and lungs over time, with the goal of developing better diagnostic tools. **You may be eligible if...** - You are between 18 and 60 years old - You have a clinical diagnosis of asthma - You have smoked very little or not at all (less than 1 pack-year) - You are in otherwise stable health - You can perform reproducible breathing tests - Your breathing test shows at least 60% of normal airflow (FEV1 > 60%) **You may NOT be eligible if...** - You are pregnant - You have a pacemaker or metallic implants that prevent MRI - You have other serious lung or heart conditions - You are currently having an asthma flare - You cannot safely stop certain inhalers temporarily before testing Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERHyperpolarized Noble Gas MRI

Hyperpolarized Helium-3 and/or Xenon-129. Noble gas magnetic resonance imaging (MRI) has recently emerged as another research approach for the non-invasive measurement of lung structure and function, including conduction of gas through airways and into airspaces. Noble gas MRI provides a complimentary and alternative method for evaluating lung disease and may be superior to CT because it allows simultaneous visualization of both airway and airspace structure and function.

Locations(1)

Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre

London, Ontario, Canada

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NCT02351141

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