Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker

This study is testing whether fluorescein — a harmless dye that causes abnormal brain tumor tissue to glow bright yellow-green under specific surgical lights — can help surgeons better see and remove brain tumors (gliomas) more completely during surgery. **You may be eligible if...** - You have been diagnosed with a brain tumor (glioma) that requires surgical removal - You are scheduled for brain surgery at a participating center - You are an adult in adequate overall health - You are willing to undergo the fluorescein dye injection as part of your procedure **You may NOT be eligible if...** - You have a known allergy to fluorescein or similar dyes - You have severe kidney or liver disease - Your tumor is a type that would not benefit from this technique - You are pregnant - You are not scheduled for surgical removal of the tumor Talk to your doctor to see if this trial is right for you.