RecruitingNCT02705287

Vitamin D Dynamics in Women

Vitamin D Dynamics in Pregnant Women and Non-Pregnant Women of Reproductive Age

Sponsor

Cornell University

Enrollment

160 participants

Start Date

Oct 28, 2024

Study Type

OBSERVATIONAL

Conditions

Pregnancy

Summary

The goal of this project is to utilize stable isotopically labeled vitamin D3 and state of the art mass spectrometric methodology to assess vitamin D dynamics during pregnancy in relation to relation to obesity and vitamin D binding protein genotype. At the conclusion of this study, the investigators will have obtained novel information on the absorption and utilization of vitamin D in women and the degree to which vitamin D utilization during pregnancy is impacted by genetic ancestry, vitamin D binding protein concentration and genotype and by excess adiposity. The long-term goal is to better understand the unique metabolism of vitamin D during pregnancy.

Eligibility

Sex: FEMALEMin Age: 20 YearsMax Age: 39 Years

Inclusion Criteria6

Self-reported White and Black women
Age 20-39
Body mass index (BMI) 1or pre-pregnancy BMI (If currently pregnant) either 18.5-24.9 kg/m2 or greater than or equal to 30 kg/m2
Singleton pregnancy
Recruited in first trimester, second trimester, or third trimester
No pregnancy complications

Exclusion Criteria15

BMI or pre-pregnancy BMI \<18.5 kg/m2
Human immunodeficiency virus (HIV) infection
Diagnosed eating disorder
Malabsorption disease
Diabetes
Elevated diastolic blood pressure (\>110 mm/Hg)
Steroid use
Substance abuse history
Current use of medications known to influence vitamin D or calcium homeostasis
Plans to travel to lower latitude during the 20-day study period
Plans to become pregnant during the study period (non-pregnant only)
Refuses to discontinue tanning bed use during study period
Refuses to discontinue vitamin or mineral supplement use during study period (non-pregnant only)
Gestational diabetes
Pregnancy hypertension