RecruitingNCT02741349

Thromboembolic and Bleeding Risk Stratification in Patients With Non-valvular Atrial Fibrillation

Impact of Clinical, Echocardiographic and Biological Parameters to the Risk of Cardiovascular Disease in Patients With Non-valvular Atrial Fibrillation.

Sponsor

Saint Antoine University Hospital

Enrollment

825 participants

Start Date

Jul 27, 2015

Study Type

OBSERVATIONAL

Conditions

Atrial Fibrillation

Summary

The aim of the present prospective study is to further develop and validate a composite risk score predicting both ischemic and bleeding risk, based on epidemiologic, clinical, biological, and/or morphologic complementary data. First, the investigators will assess the predictive performance of current clinical risk scores. Second, the investigators will assess the potential predictive value of additional markers. Third, the investigators will aim to develop a new risk score.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Adults above 18 years of age
Presenting a NVAF which is paroxysmal, persistent or permanent and documented by an electrocardiogram (ECG)
Willing and able to give written informed consent

Exclusion Criteria12

Patients presenting a clinically and echocardiographically significant valve disease defined as :
mitral stenosis with a valve area \< 2cm2
mitral insufficiency (grade 3 or 4)
aortic insufficiency (grade 3 or 4)
tricuspid insufficiency (grade 3 or 4)
aortic stenosis with a valve area \< 1.5 cm2
mechanical valve prosthèses
Secondary AF due to an acute cause (thyrotoxicosis, acute pericarditis, infection, systemic disease)
Presence of a contraindication to long term anticoagulant treatment
Absence of social security coverage
Severe psychiatric history
Impossibility of follow-up