Pancreatic Islet Transplantation Into the Anterior Chamber of the Eye

This study is testing whether insulin-producing cells from the pancreas (called islet cells) can be safely transplanted into the front chamber of the eye in patients with diabetes who have already lost vision in one eye, potentially creating a new, easily monitored site for transplantation. **You may be eligible if...** - You have at least one eye that has extensive vision loss ranging from only seeing hand movements to complete blindness - The lens in your blind eye is stable (natural or a previously placed artificial lens) - The front of your eye appears structurally normal - You are between 18 and 75 years old - You have type 1 or type 2 diabetes, with or without insulin use - Your kidney function is stable - You are able to provide written informed consent **You may NOT be eligible if...** - Both eyes still have useful vision - You have eye anatomy problems that would make the procedure unsafe - You have unstable kidney function - You are unable to comply with required follow-up visits Talk to your doctor to see if this trial is right for you.