RecruitingNot ApplicableNCT02916680
Pancreatic Islet Transplantation in the Anterior Chamber of the Human Eye - a Pilot Study
Sponsor
University Hospital, Basel, Switzerland
Enrollment
4 participants
Start Date
Mar 1, 2016
Study Type
INTERVENTIONAL
Conditions
Summary
The overall objective is to establish that transplantation of allogeneic pancreatic islet cells into the anterior chamber of a severely visual impaired diabetic human eye is safe and does not cause ophthalmic or systemic complications. Furthermore, the change in insulin production, glucose control and hypoglycaemia awareness will be assessed.
Eligibility
Min Age: 18 Years
Inclusion Criteria6
- Type 1 Diabetes (American Diabetes Association criteria)
- Kidney transplant recipient with ongoing immunosuppression
- At least one eye with extensive loss of vision from hand motion to no light perception due to damage of retina or optic nerve
- Age ≥ 18 years
- Normal cornea with good visualization of the anterior segment
- Patient not eligible or with no wish for standard pancreatic islet into the hepatic portal system or pancreas transplantation
Exclusion Criteria3
- Uncontrolled diabetic retinopathy
- Signs of current infection
- Poor visualization of the anterior chamber
Interventions
PROCEDUREPancreatic islet transplantation in the anterior chamber
Transplantation of allogeneic pancreatic islet cells into the anterior chamber of a severely visual impaired diabetic human eye
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT02916680
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