RecruitingNot ApplicableNCT03732105

Randomized Study of Adjuvant Radiotherapy After Curative Resection of HCC With Narrow Margin (RAISE)

Randomized Study of Adjuvant Radiotherapy After Curative Resection of Hepatocellular Carcinoma With Narrow Margin (≤1 cm)


Sponsor

Sun Yat-sen University

Enrollment

148 participants

Start Date

Aug 8, 2018

Study Type

INTERVENTIONAL

Conditions

Summary

RAISE is a multicenter randomized controlled trial to assess the efficacy of adjuvant radiotherapy for controlling postsurgical recurrence in HCC patients with narrow margin (≤ 1 cm) after curative resection.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying whether radiation therapy after surgery reduces the chances of liver cancer (HCC) coming back in patients whose tumors were removed with very thin (narrow) surgical margins. **You may be eligible if...** - You were diagnosed with liver cancer (HCC) and had surgery to remove it completely (confirmed by imaging) - The narrowest surgical margin was 1 cm or less - You are aged 18–75 years - Your liver function is reasonably preserved (Child-Pugh score 5–7) - Your blood counts and organ function are within acceptable ranges - Your life expectancy is at least 6 months **You may NOT be eligible if...** - There are signs of remaining cancer after surgery - Your liver function is severely impaired - You have received other cancer treatments before or after surgery for this cancer - Your blood counts or organ function fall below the required levels Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONSurgery-radiotherapy

Patients in the surgery-radiotherapy group will receive Intensity Modulated Radiation Therapy (IMRT) at a dose of 50Gy/25fraction after randomization.


Locations(1)

The First Affiliated Hospital of Sun Yat-sen University

Guangzhou, Guangdong, China

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NCT03732105


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