A Phase II Exploratory Clinical Trial of Multiple Drug Combinations in the Treatment of Advanced Esophageal Squamous Cell Carcinoma

This trial is studying different drug combinations for people with advanced esophageal squamous cell carcinoma (a type of esophageal cancer) whose disease has continued growing or spread despite prior treatment. **You may be eligible if...** - You have been diagnosed with squamous cell carcinoma of the esophagus that is advanced, has spread, or cannot be surgically removed - You are aged 18–75 years - You have already received at least one round of chemotherapy or immunotherapy that did not work or was not tolerated - You have measurable cancer on imaging scans **You may NOT be eligible if...** - You have not yet received any prior treatment for your esophageal cancer - You have a different type of esophageal cancer (e.g., adenocarcinoma) - You have severe organ problems that would make treatment unsafe - You are pregnant Talk to your doctor to see if this trial is right for you.