RecruitingNot ApplicableNCT03809728

IDENTIFICATION OF PROGNOSTIC AND PREDICTIVE BIOMARKERS IN INFLAMMATORY BOWEL DISEASE

IDENTIFICATION OF PROGNOSTIC AND PREDICTIVE BIOMARKERS OF NATURAL HISTORY AND RESPONSE TO BIOTHERAPIES IN INFLAMMATORY BOWEL DISEASE : i-BANK

Sponsor

Central Hospital, Nancy, France

Enrollment

1,000 participants

Start Date

Dec 10, 2019

Study Type

INTERVENTIONAL

Conditions

Inflammatory Bowel Diseases Crohn Disease Ulcerative Colitis

Summary

Interventional study of a group of patients with an inflammatory bowel disease (IBD; Crohn's disease (CD) or ulcerative colitis (UC)) to identify predictive and prognostic biomarkers of natural history and response to biotherapies.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Age\>=18 years
Patients with an established diagnosis of CD or UC (clinical, biological, radiological, endoscopic or histologic criteria)
Patients \>=45 kg
Affiliated member of the Social Security system

Exclusion Criteria9

Patients with an undetermined colitis
Patients with a non established diagnosis of CD
Women of childbearing age without a method of contraception
Persons covered by articles L. 1121-5, L. 1121-7 and L1121-8 of the Public Health Code
Pregnant women, breastfeeding women
\-- Age \< 18 years
Persons under legal protection
Person who does not have the capacity to consent
Persons under the age of 18 years who are deprived of their liberty by decision of a judicial or administrative authority (articles L. 3212-1 and L. 3213-1).

Interventions

PROCEDUREendoscopic biopsy

Per-endoscopic biopsies

PROCEDUREsamples of the oral cavity

7 samples of the oral cavity with a swab

PROCEDURESamples of the resected specimen

if patient has to undergo a digestive resection as part of his standard management, samples of the pathological area and samples at the end of the resection will be realised