Study on Adjuvant Chemotherapy After Total Two-field Lymph Node Dissection of Thoracic Esophageal Squamous Cell Carcinoma

This study is comparing chemotherapy approaches after surgery for esophageal squamous cell carcinoma (cancer of the food pipe). It is testing whether additional chemotherapy after a full surgical removal with lymph node dissection improves survival. **You may be eligible if...** - You have esophageal squamous cell carcinoma and had a complete surgical removal with lymph node dissection - You did not receive chemotherapy or radiation before surgery - Your cancer was at least stage T3 or had lymph node involvement (N1 or more) - At least 15 lymph nodes were removed during surgery - You are 18–75 years old and recovered well from surgery **You may NOT be eligible if...** - You received neoadjuvant (pre-surgery) chemotherapy or radiation - You had major complications after surgery - You have poor kidney, liver, or blood function - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.