RecruitingPhase 1Phase 2NCT04210492

Dose-Deescalated 3-Fraction Stereotactic Body Radiotherapy For Centrally Located Lung Cancer

Phase IB/II Trial Of Dose-Deescalated 3-Fraction Stereotactic Body Radiotherapy For Centrally Located Lung Cancer


Sponsor

Yale University

Enrollment

36 participants

Start Date

Aug 26, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this trial is to test a deescalated 3-fraction stereotactic body radiotherapy (SBRT) regimen to 45 Gray (Gy) in 3 fractions for centrally located thoracic tumors.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether delivering radiation therapy in 3 larger doses (stereotactic body radiotherapy) instead of the standard number of sessions can safely and effectively treat centrally located lung tumors near major airways or blood vessels. **You may be eligible if...** - You have a lung tumor that is 5 cm or smaller - The tumor is centrally located (near major airways, blood vessels, the esophagus, or the heart) - You are scheduled for stereotactic body radiotherapy (SBRT) **You may NOT be eligible if...** - Your tumor is larger than 5 cm - Your tumor is not centrally located near critical structures - You cannot tolerate the required radiation dose constraints Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATION45 Gray (Gy) regimen

Deescalated 3-fraction stereotactic body radiotherapy regimen to 45 Gy in 3 fractions.


Locations(6)

Smilow Cancer Hospital Care Center at Greenwich

Greenwich, Connecticut, United States

Smilow Cancer Hospital Care Center - Guilford

Guilford, Connecticut, United States

Smilow Cancer Hospital - Hamden Care Center

Hamden, Connecticut, United States

Smilow Cancer Hospital

New Haven, Connecticut, United States

Smilow Cancer Hospital Care Center - Trumbull

Trumbull, Connecticut, United States

Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, United States

View Full Details on ClinicalTrials.gov

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NCT04210492


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