Liver Transplant Combined With Neoadjuvant Chemo-radiotherapy in the Treatment of Unresectable Perihilar Cholangiocarcinoma. A Prospective Multicenter Study.

This study tests whether liver transplantation combined with chemotherapy and radiation therapy (given before transplant) can treat a type of bile duct cancer called hilar cholangiocarcinoma that cannot be surgically removed in the usual way. The goal is to see if transplant offers a cure for patients who would otherwise have no surgical options. **You may be eligible if...** - You are 70 or younger - You have unresectable hilar cholangiocarcinoma (bile duct cancer at the junction of the liver) with a tumor no more than 3 cm wide - Your overall health is good (ECOG 0-1) - You are willing to provide written consent **You may NOT be eligible if...** - You have already received chemotherapy or radiation outside of this protocol - Your cancer has spread to lymph nodes or other organs - You previously had attempted surgical removal or a percutaneous (needle through skin) biopsy of the tumor - You have another active cancer - You have an uncontrolled infection Talk to your doctor to see if this trial is right for you.