RecruitingPhase 2NCT04561492

Relevance of [68Ga]Ga -PentixaFor-PET for Initial Staging and Therapeutic Evaluation of Multiple Myeloma

Exploratory Study Evaluating the Relevance of [68Ga]Ga -PentixaFor for Initial Staging and Therapeutic Evaluation of Symptomatic Multiple Myeloma Patients in First Line Treatment or in Relapse


Sponsor

Nantes University Hospital

Enrollment

45 participants

Start Date

Sep 21, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of our study is to confirm the relevance of PET using \[68Ga\]Ga -PentixaFor ligand, in comparison with FDG, for initial staging and therapeutic evaluation of symptomatic multiple myeloma patients in first line treatment or in relapse. The prognostic value of positive CXCR4 expression will also be assessed and \[68Ga\]Ga -PentixaFor/FDG discordances explored.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This imaging study tests a new PET scan tracer called 68Ga-PentixaFor to better detect and track multiple myeloma — a cancer of the blood plasma cells — at the time of first diagnosis. Researchers hope this scan can reveal cancer that other scans might miss. **You may be eligible if...** - You are 18 or older - You have been newly diagnosed with symptomatic multiple myeloma requiring treatment - You are enrolled in the French national health service - You are in good functional health (ECOG below 2) **You may NOT be eligible if...** - You have HIV, active hepatitis B or C - You are pregnant or breastfeeding, or not using adequate contraception - Your kidney function is significantly reduced - You have another active cancer - You have uncontrolled diabetes - You are under legal guardianship Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG[68Ga]Ga-PentixaFor

Tomography by emission of positons (PET) with theradiopharmaceutic \[68Ga\]Ga-PentixaFor


Locations(5)

CHU Bordeaux

Bordeaux, France

CHU Lille

Lille, France

HCL

Lyon, France

Nantes UH

Nantes, France

APHP - Site Tenon

Paris, France

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NCT04561492


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