RecruitingNCT04668261

Longitudinal Investigation of Brain Blood Flow Changes in Neurosurgical Patients

Sponsor

University of Zurich

Enrollment

400 participants

Start Date

Jan 1, 2021

Study Type

OBSERVATIONAL

Conditions

Brain Blood Flow Impairment

Summary

Primary study objective: • Longitudinal observation of brain blood flow changes in neurosurgical patients with or without a neurosurgical intervention as compared to a healthy cohort. Secondary study objectives: * Longitudinal observation of hemodynamic patterns versus structural brain tissue changes in neurosurgical patients. * Changes in blood flow patterns and structural brain tissue after neurosurgical interventions as compared to a healthy cohort. * Determining hemodynamic imaging patterns that can be tested as novel imaging markers.

Eligibility

Min Age: 18 Years

Inclusion Criteria10

Patients:
Male and Female subjects \>18 years of age
Written informed consent after participants' information. Foreign speaking patients should be accompanied by a person with sufficient German language proficiency to act as a translator
Neurosurgical diseases with the potential to alter blood flow to the brain:
Cerebrovascular disease
Brain tumors
Normal Pressure Hydrocephalus
Healthy subjects:
Male and Female subjects \>18 years of age
Written Informed Consent by the participant after information about the project. Foreign speaking healthy subjects should be accompanied by a person with sufficient German language proficiency to act as a translator

Exclusion Criteria16

Patients:
Unwilling or unable to co-operate with breathing maneuvers
Respiratory or cardiac limitations to breathing through a mask
Medical contra-indications to limited hypercapnia (high CO2 - 50 mmHg) or hypocapnia (low CO2 - 30 mmHg) (i.e., known increased intracerebral pressure, metabolic acidosis or alkalosis)
Standard contraindications for MRI scanning
Verbal confirmed pregnancy
Known multiple intracranial diseases
Presence of intracranial hemorrhage within the last 3 months
Symptomatic increased intracranial pressure
Healthy subjects:
Unwilling or unable to co-operate with breathing maneuvers
Respiratory or cardiac limitations to breathing through a mask
Medical contra-indications to limited hypercapnia (high CO2 - 50 mmHg) or hypocapnia (low CO2 - 30 mmHg) (i.e., known increased intracerebral pressure, metabolic acidosis or alkalosis)
Standard contraindications for MRI scanning
Verbal confirmed pregnancy
Anamnesticly a history of neurological disease or current neurological deficits.

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Interventions

OTHERAdvanced imaging investigation

MRI imaging

Locations(1)

University Hospital Zurich

Zurich, Switzerland

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NCT04668261