Fluorescence Image Guided Foregut Surgery
Prospective Study on the Contribution of Fluorescence in the Guidance of Lymphadenectomy and in Peroperative Evaluation of Pre-anastomotic Tissue Perfusion in Laparoscopic Esogastric Oncologic Resections
IHU Strasbourg
60 participants
Apr 1, 2021
INTERVENTIONAL
Conditions
Summary
A high number of resected lymph nodes is an independent prognostic factor for improved survival after esophagectomy or gastrectomy for cancer. The quality of the lymphadenectomy is operator-dependent, as is the evaluation of the vascularization of the digestive structures that are anastomosed to restore digestive continuity after esophago-gastric resection. The aim of the study is to evaluate the impact of Indocyanine Green (ICG) and near infra-red (NIR) fluorescence imaging guidance in terms of number of lymph nodes resected and quality of gastrointestinal tract anastomoses in esophagogastric cancer surgery.
Eligibility
Inclusion Criteria5
- Man or woman over 18 years old.
- Patient with resectable primitive esophageal or gastric cancer confirmed by biopsy without distant metastases
- Patient with no contraindications to anaesthesia and performance of esophageal and/or gastric surgery
- Patient able to receive and understand information related to the study and give written informed consent.
- Patient affiliated to the French social security system.
Exclusion Criteria8
- Patient undergoing emergency surgery (hemorrhage, occlusion or perforation).
- Presence of distant metastasis
- Patient at risk of allergy to indocyanine green or to other fluorescent compounds
- Pregnant or lactating patient.
- Patient in exclusion period (determined by a previous or a current study).
- Patient under the protection of justice.
- Patient under guardianship or trusteeship.
- Patient deprived of liberty
Interventions
ICG injection around tumor each four direction by endoscopy followed by NIR fluorescence guidance laparoscopic or robotic esophagectomy or gastrectomy
Locations(1)
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NCT04734821