RecruitingNot ApplicableNCT04814420

Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study


Sponsor

Tulane University

Enrollment

60 participants

Start Date

Jul 12, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The investigators hypothesize that Obstructive Sleep Apnea (OSA) is an independent risk factor for atrial fibrosis development. The investigators aim to prove the presence of atrial fibrosis on Delayed Enhancement Magnetic Resonance Imaging (DE-MRI) in OSA patients without atrial fibrillation (AF).


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This pilot study is exploring whether sleep apnea — a condition where breathing repeatedly stops during sleep — causes scarring in the heart's upper chambers (atria). Scarring can lead to an irregular heartbeat called atrial fibrillation. Researchers want to see if the severity of sleep apnea is linked to how much scarring develops. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with sleep apnea (mild, moderate, or severe) confirmed by a sleep study - You may or may not have a history of atrial fibrillation (irregular heartbeat) **You may NOT be eligible if...** - You do not have a confirmed sleep apnea diagnosis - You fall outside the 18–75 age range Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEDelayed enhancement magnetic resonance imaging (DE-MRI)

The patient will be injected with late gadolinium enhancement (0.01 mmol/kg standard dosage), which is a contrast agent used in clinical practice in MRI imaging studies. The contrast agent is used to enhance specific regions/tissues on MRI and, in this study, will allow the investigators to identify fibrotic tissue within the heart. The patient then undergoes the MRI sequence, which lasts approximately 20-25 minutes. Images will be reviewed for quality by trained technicians. This will be repeated after 6 months.


Locations(3)

East Jefferson General Hospital

New Orleans, Louisiana, United States

University Medical Center

New Orleans, Louisiana, United States

Tulane Doctors - Speciality Care - Napoleon

New Orleans, Louisiana, United States

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NCT04814420


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