RecruitingNot ApplicableNCT04936009

Transcranial Magnetic Stimulation (TMS) Study for Adults With Autism Spectrum Disorder (ASD)

Noninvasive Brain Stimulation to Treat Core Social Deficits in Autism Spectrum Disorder


Sponsor

Yale University

Enrollment

60 participants

Start Date

Mar 17, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This is a randomized interventional study designed to evaluate the effects of repetitive Transcranial Magnetic Stimulation (rTMS) on neural and behavioral facets of social cognition in adults with autism spectrum disorder (ASD).


Eligibility

Min Age: 18 YearsMax Age: 40 Years

Inclusion Criteria2

  • Individuals between the ages of 18 and 40 years old with typical development or with a diagnosis of autism spectrum disorder.
  • Individuals able to participate in an EEG and eye-tracking experiment.

Exclusion Criteria9

  • Participants reporting significant head trauma or serious brain illness.
  • Participants with major psychiatric illness that would preclude completion of study measures.
  • Participants with a history of serious medical illness, stroke, seizures, epileptiform EEG abnormalities, or family history of seizures.
  • Participants taking prescription medications that may affect cognitive processes under study.
  • Participants who have taken alcohol or recreational drugs within the preceding 24 hours.
  • Females of known/suspected pregnancy or who test positive on a pregnancy test.
  • Participants with a history of metalworking or injury by shrapnel or metallic objects are also excluded.
  • Participants with a history of prior TMS therapy or use of an investigational drug within 12 weeks of visit.
  • Participants with an IQ (intelligence quotient) below 80.

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Interventions

BEHAVIORALTranscranial Magnetic Stimulation (TMS)

Subjects will receive both active and sham TMS in a randomized crossover assignment involving two study sessions


Locations(1)

Yale University Child Study Center

New Haven, Connecticut, United States

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NCT04936009


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