Neoadjuvant Immunotherapy Plus CRT Versus Neoadjuvant CRT for Locally Advanced Resectable ESCC

This study is comparing two approaches before surgery for people with locally advanced squamous cell cancer of the oesophagus (food pipe): standard chemoradiation (chemotherapy plus radiation) versus chemoradiation combined with immunotherapy. **You may be eligible if...** - You have been diagnosed with squamous cell carcinoma of the thoracic (chest) oesophagus, confirmed by biopsy before any treatment - Your cancer is stage II or III (locally advanced but potentially operable) - You are between 18 and 75 years old - You are in good physical condition (ECOG 0–1) with expected survival over 12 months - You have adequate heart, lung, and bone marrow function **You may NOT be eligible if...** - Your cancer is of a different type (e.g., adenocarcinoma) or in a different location (e.g., cervical oesophagus) - Your cancer has spread to other organs (metastatic, stage IV) - Your heart, lung, or blood function is inadequate for treatment - You have an active autoimmune condition or are on immunosuppressive drugs Talk to your doctor to see if this trial is right for you.