RecruitingNot ApplicableNCT05112705

Diagnosing Deep-vein Thrombosis Early in Critically Ill Patients

Diagnosing Deep-vein Thrombosis Early in Critically Ill Patients (DETECT) Trial

Sponsor

King Abdullah International Medical Research Center

Enrollment

1,800 participants

Start Date

Mar 21, 2023

Study Type

INTERVENTIONAL

Conditions

Pulmonary Embolism Deep Vein Thrombosis

Summary

The DETECT randomized controlled trial addresses the question of whether surveillance ultrasound in critically ill patients by facilitating DVT detection reduces the incidence of PE and lowers all-cause 90-day mortality. The primary outcome is 90-day all-cause mortality.

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Medical, surgical or trauma ICU patients ≥18 years old.
Patients who are expected to stay in the ICU more than 2 calendar days (unlikely to be discharged out of ICU on the day of admission or on the next day).

Exclusion Criteria9

Patients with DVT or PE diagnosed within the last year.
Patients receiving chronic systemic anticoagulation.
Patients who have received up to the time of ICU admission or are receiving therapeutic doses of anticoagulation with UFH, LMWH, or other anticoagulants.
Inability or contraindication to obtain adequate ultrasound on the lower extremities (Burns in the lower extremities, lacerations, active skin infection, \& ischemic limb in the legs, large dressings in the thighs that prevent adequate ultrasounds OR amputated foot or leg on one or two sides)
Patients with Inferior Vena Cava (IVC) Filter.
Known or suspected pregnancy.
Limitation of life support, life expectancy \<7 days or palliative care.
Previously enrolled in DETECT trial within the last 180 days.
Enrolled in another trial for which co-enrolment is not approved.

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