RecruitingNCT05286736

Neuroplasticity in Parkinson's Disease

Plasticity of Motor Systems in Early Stage Parkinson's Disease

Sponsor

University of Minnesota

Enrollment

50 participants

Start Date

Mar 1, 2021

Study Type

OBSERVATIONAL

Conditions

Parkinson Disease Parkinson

Summary

The purpose of this project is to increase our understanding of the early state and temporal evolution of neuroplastic changes in the cortex and subthalamic nucleus (STN) of people with PD, and the relationship of these changes to the emergence and expression of PD motor and non-motor signs. Neurophysiological biomarkers derived from this work may be important for the early detection and prediction of progression of disease. They can also provide the means to assess the efficacy of interventions designed to prevent or slow disease progression.

Eligibility

Min Age: 21 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study examines how the brain adapts and reorganizes itself (neuroplasticity) in people with early Parkinson's disease compared to healthy individuals. It uses brain stimulation (transcranial magnetic stimulation, or TMS) and walking tests to measure how the brain learns and responds to movement training. **You may be eligible if...** - You have been diagnosed with idiopathic (typical) Parkinson's disease by a movement disorders specialist AND are not yet taking levodopa or dopamine medications, OR - You are a healthy adult who matches the Parkinson's participant in age and sex - In both cases, you must be able to walk independently for 50 meters without a walking aid **You may NOT be eligible if...** - You have dementia or significant cognitive impairment - You have a significant musculoskeletal disorder affecting your limbs - You have a history of bipolar disorder, PTSD, or major depression - You have had deep brain stimulation surgery or other neurosurgery for Parkinson's - For the TMS portion: history of seizures, stroke, multiple sclerosis, or traumatic brain injury - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTNeuroimaging

This project will use neuroimaging (7T MRI: structural, diffusion and rest-state functional MRI) and non-invasive brain stimulation (TMS: PAS. SAI) techniques to quantify structural and functional changes in brain function.

DIAGNOSTIC_TESTQuantitative assessments

Quantitative assessments of motor function (gait, gait initiation, reactive balance, bradykinesia, repetitive alternating movements, rigidity, stop-signal reaction time), and neuropsychological function

Locations(1)

University of Minnesota

Minneapolis, Minnesota, United States

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