Targeted Optical Biopsy for Local Rectal Scars in Rectal Cancer Patients After Neoadjuvant Chemoradiotherapy
Use of Probe-based Confocal Laser Endomicroscopy to Perform Targeted Optical Biopsy for Local Rectal Scars in Rectal Cancer Patients After Neoadjuvant Chemoradiotherapy
Nanfang Hospital, Southern Medical University
68 participants
Nov 4, 2021
INTERVENTIONAL
Conditions
Summary
Currently, low concordance (36%) is found between clinical complete response and pathologic complete response in patients with rectal cancer after neoadjuvant chemoradiotherapy. Probe-based confocal laser endoscopy (pCLE) provides a promising targeted optical biopsy to evaluate the response to neoadjuvant chemoradiotherapy. The aim of this study is to investigate whether pCLE-targeted optical biopsy can improve the accuracy of preoperative endoscopic biopsy for local rectal scars in rectal cancer patients after neoadjuvant chemoradiotherapy.
Eligibility
Inclusion Criteria6
- Age from over 18 to under 80 years
- American Society of Anesthesiology(ASA) score class I,II,or III
- Locally advanced rectal cancer
- Patient has completed standard neoadjuvant therapy
- Expected surgical resection
- Written informed consent
Exclusion Criteria3
- Pregnant or lactating women
- Acute renal insufficiency or stage II to IV chronic renal insufficiency
- Patients with allergic constitution
Interventions
After intravenous injection of fluorescein sodium, pCLE-based targeted optical biopsy will be performed.
Locations(1)
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NCT05316103