RecruitingNot ApplicableNCT05327517

Surgery or Chemoradiotherapy for Cervical Esophageal Cancer

Surgery Versus Definitive Chemoradiotherapy for Resectable Cervical Esophageal Squamous Cell Carcinoma: A Prospective Multicenter Open-Label Clinical Trial


Sponsor

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Enrollment

192 participants

Start Date

Apr 10, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

To compare surgery with definitive chemoradiotherapy for patients with resectable cervical esophageal squamous cell carcinoma.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing surgery versus combined chemotherapy and radiation (chemoradiotherapy) for treating cancer of the cervical esophagus (the upper part of the food pipe in the neck), to find out which approach gives better outcomes. **You may be eligible if...** - You are 18–75 years old - You have been diagnosed with resectable squamous cell carcinoma of the cervical esophagus - Your cancer has not spread to distant organs (stages T1b–T4a, N0–N3, M0) - Your blood counts and organ functions are within acceptable ranges - You have an ECOG performance status of 0 or 1 (meaning you are fully active or mildly limited) **You may NOT be eligible if...** - You have another active cancer - You have a mental illness preventing participation - You have a bleeding disorder - You are pregnant or breastfeeding - You have a known allergy to paclitaxel or cisplatin Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREEsophagectomy

Patients receive esophagectomy or definitive chemoradiotherapy according to patient preference


Locations(1)

Cancer Hospital Chinese Academy of Medical Sciences

Beijing, China

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NCT05327517