RecruitingNCT05357768
Global collaboRAtion on CIC-DUX4, BCOR-CCN3, High-grade Undifferentiated Round Cell Sarcoma (URCS) Project
Sponsor
Istituto Ortopedico Rizzoli
Enrollment
260 participants
Start Date
Jun 11, 2019
Study Type
OBSERVATIONAL
Conditions
Summary
Experimental study with biological material : case series review of clinical and histological data
Eligibility
Inclusion Criteria3
- Patients with undifferentiated round cell sarcomas treated from 01 January 1983 and all new patients will be included.
- Clinical and outcome information available.
- Histological slides/formalin-fixed paraffin-embedded tissue tumor blocks from archive available to perform the histology analysis/frozen tissue representative of the tumor available.
Exclusion Criteria2
- Diagnosis different from undifferentiated round cell sarcomas
- Patient with no clinical or outcome information available
Interventions
OTHERdata collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue
Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue of cases negative for all Ewing's sarcoma molecular fusions, will be analyzed for the presence of CIC-DUX4 / BCOR-CCNB3 translocations fusion at each Institution. Treatment, outcome, and prognostic factors will be related with the molecular re-classification.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05357768