PHL Treatment in Pancreatic Cancer

This study is testing an experimental drug combination called PHL (which includes hydroxychloroquine and other medications) alongside standard chemotherapy and radiation for people with pancreatic cancer that can be surgically removed. Researchers want to know if adding PHL before surgery improves outcomes. **You may be eligible if...** - You have newly diagnosed pancreatic cancer confirmed by biopsy - Your cancer has not spread (non-metastatic) and is planned for surgery - You are planned to receive at least 3 months of chemotherapy (FOLFIRINOX) followed by chemoradiation and then surgery - You are 18 or older and in reasonably good health - Your organ function (liver, kidneys) is within normal range **You may NOT be eligible if...** - Your cancer has spread to other parts of the body - You are currently taking hydroxychloroquine or blood pressure medications called ARBs - You are pregnant or breastfeeding - You have a history of retinal disease, low blood pressure, or high calcium levels - You have serious kidney disease (creatinine clearance below 30 mL/min) - You have significant heart rhythm problems (QT prolongation or AV block) Talk to your doctor to see if this trial is right for you.