RecruitingNCT05482126

Sensory Filtering in the Human Basal Ganglia as a Mechanism of Parkinson's Disease

Sponsor

University of Alabama at Birmingham

Enrollment

30 participants

Start Date

Jun 8, 2022

Study Type

OBSERVATIONAL

Conditions

Parkinson Disease

Summary

The investigators are investigating the brain activity associated with sensory information in movement disorders in order to improve treatment of these symptoms beyond what is currently available.

Eligibility

Min Age: 18 YearsMax Age: 89 Years

Inclusion Criteria7

Age \>18 years
Clinically definite, advanced idiopathic PD based on consensus criteria.
Normal, or essentially normal, preoperative brain MRI.
Patient is available for follow-up visits over the length of the study
Patient has elected to undergo DBS surgery as part of routine care, and subthalamic nucleus (STN) is determined as the appropriate surgical target
Age \>18 years.
No diagnosis of PD, other movement disorder, or other significant neurological disease.

Exclusion Criteria9

Age \<18 years.
Medical contraindications such as current uncontrolled hypertension, heart disease, coagulopathy, or other conditions that might increase the risk of surgery
Diagnosis or suspicion of atypical Parkinsonism (PSP, MSA, CBD) or drug-induced Parkinsonism, or significant neurological disease other than PD.
Diagnosis of psychogenic movement disorder based on consensus criteria
Prior DBS surgery or ablation
Clinical dementia and/or Dementia Rating Scale (DRS) score of \<5th percentile adjusted for age and education level, based upon routine pre-op NP testing.
Unable to withhold dopaminergic medications for at least 12 hours prior to scheduled visit
Age \<18 years.
Previous diagnosis of PD, other movement disorder, or other significant neurological disease.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIAGNOSTIC_TESTIntraoperative Behavioral Testing

During DBS surgery, tasks will be administered via a tablet PC or mounted monitor, and the subject may hold a response box, joystick, or dynamometer to record responses. During task periods, sensory stimuli will be delivered to the participant, who may be asked to perform a motor behavior in response. Stimuli will consist of audiovisual cues presented on a computer screen, vibration applied to specific parts of the body via a tactor, mild electrical pulses delivered through the skin of specific parts of the body via the attached EMG electrodes, and/or a movement of the arm or joint. Motor responses will consist of simple movements such as finger-tapping or hand-opening, or use of a joystick or dynamometer to move a computer cursor on the screen. Participants may be asked to respond only to a particular sensory stimulus and ignore others, in order to modulate the relevance of each stimulus to the task.

DIAGNOSTIC_TESTBehavioral Testing

In the lab, tasks will be administered via a tablet PC or mounted monitor, and the subject may hold a response box, joystick, or dynamometer to record responses. During task periods, sensory stimuli will be delivered to the participant, who may be asked to perform a motor behavior in response. Stimuli will consist of audiovisual cues presented on a computer screen, vibration applied to specific parts of the body via a tactor, mild electrical pulses delivered through the skin of specific parts of the body via the attached EMG electrodes, and/or a movement of the arm or joint. Motor responses will consist of simple movements such as finger-tapping or hand-opening, or use of a joystick or dynamometer to move a computer cursor on the screen. Participants may be asked to respond only to a particular sensory stimulus and ignore others, in order to modulate the relevance of each stimulus to the task.