RecruitingPhase 4NCT05483465

The Effect of NAD Supplementation on Brain Vascular Health in Aging

Effects of NAD Restoration on Neurovascular Coupling in Community Dwelling Older Adults

Sponsor

University of Oklahoma

Enrollment

214 participants

Start Date

May 3, 2023

Study Type

INTERVENTIONAL

Conditions

Aging

Summary

Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.

Eligibility

Min Age: 60 YearsMax Age: 85 Years

Inclusion Criteria5

Age ≥60 and ≤85 years of age
Adequate hearing and visual acuity to participate in the examinations
Ability to read and write in English
Competence to provide informed consent.
Mini-Mental State Exam score ≥24

Exclusion Criteria8

Vision or hearing impairment that would impair the ability to complete study assessments
Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
Cerebrovascular accident other than TIA within 60 days prior to Visit 0
Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse
Abnormal kidney function (creatinine \>2mg/dL or EGFR \<30mL/min) by most recent labs within 6 months prior to Visit 0
Elevated liver enzymes (AST and/or ALT above x2 upper limit of normal) by most recent labs within 6 months prior to Visit 0
Treatment with other NAD enhancers (Nicotinamide riboside or nicotinamide mononucleotide) within 4 weeks prior to randomization.
Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol

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