RecruitingNCT05496582

The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma

The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma: A Case-control Study

Sponsor

Shanghai University of Traditional Chinese Medicine

Enrollment

100 participants

Start Date

Nov 1, 2022

Study Type

OBSERVATIONAL

Conditions

Asthma

Summary

Asthma is one of the most common chronic respiratory diseases. Previous study found a series of differentially expressed genes and proteins (transgelin-2, metallothionein-2, ezrin) in asthmatic rat. The aim of the study is to investigate the changes and associations of these gene with asthma in human.

Eligibility

Min Age: 14 YearsMax Age: 75 Years

Inclusion Criteria5

Males or females, aged 14-75 years;
Patients with a definite diagnosis of bronchial asthma;
The diagnosis of asthma according to the Global Initiative for Asthma (GINA), with positive bronchodilator responsiveness (reversibility) test;
Healthy volunteers without respiratory symptoms such as cough, wheezing, chest tightness or dyspnea;
Agree with all procedures in this trial by signing a written informed consent form.

Exclusion Criteria6

Patients with chronic obstructive pulmonary disease or other airway disease;
Complicated with other severe primary diseases (including hypertension, cancer, hyperthyroidism, bronchiectasia, cardiac insufficiency) and conditions that would prevent participation in the trial or put the participant at risk;
Women who are known to be pregnant or breastfeeding;
Not willing to participate;
Psychiatric history and neurological disorders can not work normally;
Other conditions that the researcher considers inappropriate to participate in this study.