RecruitingNot ApplicableNCT05519319

Safety and Efficacy of PDT vs RFA vs PDT+RFA for the Treatment of Extrahepatic Cholangiocarcinoma

Clinical Effect and Safety of Photodynamic Therapy Versus Radiofrequency Ablation Versus Photodynamic Therapy Plus Radiofrequency Ablation for Unresectable Extrahepatic Cholangiocarcinoma

Sponsor

First People's Hospital of Hangzhou

Enrollment

70 participants

Start Date

Jan 1, 2023

Study Type

INTERVENTIONAL

Conditions

Bile Duct Cancer Extrahepatic Cholangiocarcinoma

Summary

A median survival period of 3 to 6 months is the prognosis for patients with advanced, unresectable EHCC. For patients with locally advanced, unresectable EHCC, effective management of tumor growth is the only option to increase stent patency and survival time. In patients with cholangiocarcinoma, photodynamic therapy (PDT) is therapy that has been shown to improve stent patency and overall survival (OS). Endoscopic radiofrequency ablation (RFA) has been demonstrated in numerous studies to prolong the life spans of individuals with malignant biliary obstruction . In the literature, comparing the clinical efficacy and adverse outcomes of these two endoscopic procedures is rare.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing three treatments for bile duct cancer outside the liver (extrahepatic cholangiocarcinoma) that cannot be surgically removed: photodynamic therapy (PDT), radiofrequency ablation (RFA), or a combination of both, to see which works best. **You may be eligible if...** - You have been diagnosed with bile duct cancer (cholangiocarcinoma) confirmed by biopsy or lab test - Your cancer cannot be surgically removed because it has grown into major blood vessels - You have not received any prior cancer treatment - Your blood counts and organ function are within acceptable limits - Your overall health allows you to undergo the procedure (Karnofsky score ≥50) **You may NOT be eligible if...** - Your cancer has spread to other organs (liver, lungs, or elsewhere) - You have another type of active cancer - You are pregnant or breastfeeding - You have had previous stomach or bowel surgery that would affect the procedure - You have a history of alcohol or drug abuse Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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