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RecruitingNCT05636605

Analysis of the Microenvironment of Lung Cancer and Exploration of the Mechanism of Resistance to Immunotherapy

Sponsor

The Fourth Affiliated Hospital of Zhejiang University School of Medicine

Enrollment

200 participants

Start Date

Jan 1, 2018

Study Type

OBSERVATIONAL

Conditions

Lung Cancer

Summary

The investigators plan to conduct a multiomics analysis（such as, Genomics, proteomics, single cell RNA sequencing, space transcriptomics）of tumor tissue and blood, aiming at analyzing tumor heterogeneity, mapping the microenvironment map of lung cancer and exploring the mechanism of sensitivity and resistance to anti-PD1/PD-L1 antibodies.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria2

  • Histopathology or hemology diagnostics of lung cancer
  • Patients have never received any antineoplastic therapy

Exclusion Criteria5

  • Within 5 years or at the same time, there are other active malignancies
  • Currently participating in interventional clinical research treatment, or received other research drugs or used research devices within 4 weeks before the first administration
  • Active autoimmune diseases requiring systemic treatment (such as the use of disease relieving drugs, glucocorticoids or immunosuppressants) occurred within 2 years before the first administration
  • The study was receiving systemic glucocorticoid treatment (excluding local glucocorticoids by nasal spray, inhalation or other means) or any other form of immunosuppressive therapy within 7 days before the first administration; Note: It is allowed to use glucocorticoid with physiological dose (prednisone ≤ 10mg/day or equivalent)
  • Known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation

Interventions

DIAGNOSTIC_TESTMultiomics analysis

Genome, proteomics, single cell RNA sequencing, and space transcriptome sequencing，etc

Locations(1)

The Fourth Affiliated Hospital of Zhejiang University

Yiwu, Zhejiang, China

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NCT05636605

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