RecruitingNCT05656586

Udall Project 2 Aim 2A&C

Mechanisms and Effects of Pallidal Deep Brain Stimulation on Levodopa Resistant Motor Signs in Parkinson's Disease; Udall Project 2 Aim 2A&C

Sponsor

University of Minnesota

Enrollment

36 participants

Start Date

Jan 1, 2023

Study Type

OBSERVATIONAL

Conditions

Parkinson Disease

Summary

This protocol will leverage the novel (on-label, FDA-approved) local field potential measuring capability of the Medtronic Percept™ PC or RC DBS system to study the effects of globus pallidus internus, globus pallidus externus (GPi, GPe), and subthalamic nucleus (STN) DBS on: the wash-out and wash-in dynamics of motor behavior and local field potentials (LFPs) and correlations between fluctuations in gait and LFPs during activities of daily living (recorded over a minimum of 4 weeks). These experiments will elucidate the relationships between LFPs oscillations, lower limb function, postural control and gait performance.

Eligibility

Plain Language Summary

Simplified for easier understanding

This study looks at how deep brain stimulation (DBS) — a device implanted in the brain to reduce tremors and other movement symptoms — affects the brain signals in people with Parkinson's disease, with the goal of improving how DBS is tuned and personalized. **You may be eligible if...** - You have Parkinson's disease and are already being treated with DBS in a specific brain region (the globus pallidus, or GP) - You have a Medtronic Percept DBS system implanted - Your DBS system has been active for at least 3 months - For the at-home portion: your DBS settings are compatible with the sensing feature **You may NOT be eligible if...** - You have significant musculoskeletal problems affecting your ability to do movement tasks - You have dementia or significant cognitive impairment - You have other serious neurological conditions - You lack the capacity to give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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