Barrett's Esophagus and Esophageal Adenocarcinoma, Searching for Reliable Diagnostic RNA Plasma-based Biomarkers

This study is looking for RNA-based biomarkers in blood that could help diagnose Barrett's esophagus (a precancerous condition of the food pipe) and esophageal adenocarcinoma (a type of food pipe cancer) — potentially allowing earlier and less invasive detection. **You may be eligible if...** - You are over 18 years old - You have a confirmed diagnosis of Barrett's esophagus (with a segment longer than 3 cm) OR esophageal adenocarcinoma confirmed by biopsy - You have no other active cancer - You are not pregnant or breastfeeding - You are mentally capable of giving informed consent **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have an active bacterial, viral, or fungal infection - You have liver cirrhosis - You are on blood thinners or have esophageal varices (a bleeding risk during biopsy) - You have esophageal squamous cell carcinoma (a different type of food pipe cancer) - You currently have H. pylori infection - You have a psychiatric condition that impairs your ability to understand or consent Talk to your doctor to see if this trial is right for you.