7 Tesla MRI Brain Imaging to Decipher Filgotinib's Mode of Analgesic Action in Rheumatoid Arthritis

This study uses ultra-high-resolution 7 Tesla MRI brain imaging to understand how filgotinib — a drug used to treat rheumatoid arthritis — reduces pain. Researchers want to see whether the drug changes brain activity in ways that explain its pain-relieving effects. **You may be eligible if...** - You are 18–74 years old with moderate to severe active rheumatoid arthritis - Your doctor has already prescribed filgotinib for your arthritis - You are right-handed **You may NOT be eligible if...** - You have severe physical impairments (e.g., blindness, paralysis, deafness) - You are pregnant or breastfeeding - You have severe claustrophobia or cannot have an MRI - You have a major neurological condition such as multiple sclerosis, stroke, or traumatic brain injury - You have previously used other targeted arthritis drugs (JAK inhibitors like baricitinib or tofacitinib) Talk to your doctor to see if this trial is right for you.