RecruitingNot ApplicableNCT05724992

Familial Pancreatic Cancer PROPHilation Program in Italy

Standardised Genetic Profiling of Subjects Belonging to the Italian Multicenter Registry of Prospective Surveillance of Subjects at Genetic Risk of Pancreatic Cancer

Sponsor

Associazione Italiana per lo Studio del Pancreas

Enrollment

3,000 participants

Start Date

Dec 20, 2022

Study Type

INTERVENTIONAL

Conditions

Candidates for Hereditary Pancreatic Cancer Testing

Summary

The goal of the PROPH-ITA Study is to perform genetic testing in family members of pancreatic cancer patients who may have a genetic predisposition. The subjects belong to the Italian Registry of Families At Risk of Pancreatic Cancer (IRFARPC, #NCT04095195). This investigational study will assess the genetic background of subjects with familiarity with pancreatic cancer only. Participants may accept to undergo genetic testing as part of the IRFARPC registry, through a saliva-swab-based 41-gene panel test. Up to 3,000 participants will be enrolled in this study.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study offers genetic testing to families with a history of pancreatic cancer in Italy, to identify inherited gene mutations that may increase cancer risk and guide prevention strategies. **You may be eligible if...** - You are enrolled in the Italian Registry for Familial and Hereditary Pancreatic Cancer (IRFARPC) - You have a family history of pancreatic cancer - You are willing to provide a saliva sample for genetic testing **You may NOT be eligible if...** - You already have a known genetic mutation associated with pancreatic cancer risk Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

GENETICSaliva swab testing

41 pancreatic cancer predisposition genes will be tested through a saliva-based swab

Locations(1)

Chirurgia generale e del Pancreas Azienda Ospedaliera Universitaria Integrata

Verona, Italy

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NCT05724992