SBRT of Metastases Following Neo-adjuvant Treatment for Colorectal Cancer With Synchronous Liver Metastases

This trial is studying stereotactic body radiation therapy (SBRT) — a highly precise, high-dose form of radiation — to treat liver metastases (cancer that has spread to the liver) in people with colorectal cancer. SBRT is given after initial chemotherapy and before or after removal of the primary colon or rectal tumor. **You may be eligible if...** - You are 18 or older with colorectal cancer and 1–5 liver metastases (maximum 5 cm in size) that were identified within 3 months of diagnosis - Your liver lesions are confined to one lobe of the liver and are potentially treatable with SBRT - You are planning to have surgery to remove the primary colorectal tumor with curative intent - Your ECOG performance status is 0–2 (functional enough for treatment) **You may NOT be eligible if...** - You have more than 5 liver lesions or they are too large or widespread - Cancer has spread to organs beyond the liver - You are not a candidate for curative-intent surgery on the primary tumor Talk to your doctor to see if this trial is right for you.