RecruitingPhase 2NCT05839535

Enhancing Modulation Effects of Baduanjin Through Neuromodulation for Knee OA

Enhancing Modulation Effects of Baduanjin Through Non-invasive Neuromodulation for Knee Osteoarthritis

Sponsor

Massachusetts General Hospital

Enrollment

140 participants

Start Date

Mar 5, 2024

Study Type

INTERVENTIONAL

Conditions

Knee Osteoarthritis

Summary

This study will combine brain imaging and neuromodulation tools to investigate the underlying neurobiological mechanisms of exercises. The findings will enhance our understanding of the mechanisms underlying mind-body exercise and facilitate the development of new pain management approaches.

Eligibility

Min Age: 45 YearsMax Age: 75 Years

Inclusion Criteria6

Volunteers 45-75 years of age
Meet the Classification Criteria of the American College of Rheumatology for osteoarthritis of the right and/or left knee for at least the past 3 months;
Physically able to participate in the BDJ and stretching control education programs
Willing to complete the 12-week study
Can participate in MRI scan
Ability to read and understand English; English can be a second language provided that the patient feels he or she can understand all the questions used in the assessment measures

Exclusion Criteria7

Has performed BDJ, Tai Chi, Yoga, other mind-body intervention, physical therapy, or routine exercise (running, cycling, etc.) regularly in the past year
Serious medical conditions limiting ability of patient to participate in the study, such as symptomatic cardiovascular disease, symptomatic pulmonary disease requiring supplemental oxygen, uncontrolled metabolic diseases, severe renal and liver disease
Has had intra-articular steroid injections or reconstructive surgery in the prior 3 months on the affected knee; any intra-articular hyaluronic acid injections in the previous 6 months
Patient Mini-Mental Status Examination score below 24 \[293\]
Unable to walk without a cane or other assistive device
The intent to undergo surgery during the time of involvement in the study
Plan to permanently relocate from the region during the trial period