RecruitingNCT05939232
Registry of X-linked Adrenoleukodystrophy
Sponsor
Beijing Tiantan Hospital
Enrollment
200 participants
Start Date
Jul 20, 2023
Study Type
OBSERVATIONAL
Conditions
Summary
This study is a observational study conducted through recruiting X-linked adrenoleukodystrophy (X-ALD) patients, to build a comprehensive evaluation and long-term follow-up platform for X-ALD patients, and to provide a theoretical basis for the treatment and management of X-ALD patients.
Eligibility
Min Age: 6 YearsMax Age: 70 Years
Inclusion Criteria10
- X-ALD group：
- Meet the diagnostic criteria of X-ALD and supported by the results of genetic and very long chain fatty acid (VLCFA) test;
- Age: 6 - 70 years old;
- Able to communicate normally, and complete the test of scale as instructed (confirmed by the field test of scale);
- Sign the informed consent.
- Carrier-control group:
- Healthy people who have no significant difference in age, sex and education comparing with the X-ALD group, volunteer to participate in this study, could complete the test of scale as instructed, and meet the following criteria:
- Eligible for asymptomatic carriers in genetic tests (preference of patient's mother and close relatives);
- Age: 6 - 70 years old, able to complete the test of scale as instructed (confirmed by the field test of scale);
- No history of psychiatric diseases.
Exclusion Criteria8
- Other hereditary diseases;
- Other severe central nervous diseases;
- History of surgery of brain or eye;
- Psychiatric and psychological diseases, such as anxiety and depression;
- Metal foreign body or prosthesis in the human body (such as pacemaker and insulin pump), claustrophobia, and other MRI contraindications;
- History of surgery associated with gastrointestinal tract;
- No informed consent;
- Unable to tolerate MRI or eye related tests.
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05939232