Changes in Inhibition and Valuation After Eating
Dynamic Neural Computations Underlying Cognitive Control in Bulimia Nervosa
Icahn School of Medicine at Mount Sinai
150 participants
Dec 12, 2023
INTERVENTIONAL
Conditions
Summary
An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment. This project aims to understand how predictions and value-based decisions about control may be abnormally influenced by eating in individuals with BN, thereby maintaining cycles of binge eating, purging, and restriction.
Eligibility
Inclusion Criteria6
- Female
- Aged 18 to 45 years
- Current BMI greater than or equal to 18.5kg/m2 but under 30kg/m2
- Right-handed
- English-speaking
- Meet DSM-5 criteria for bulimia nervosa
Exclusion Criteria6
- Medical instability
- Ongoing medical treatment, medical condition, or psychiatric disorder that may interfere with study variables or participation
- Shift work
- Pregnancy, planned pregnancy, or lactation during the study period
- Allergy to any of the ingredients in or unwillingness to consume the standardized meal or unwillingness to drink water during the fasting period
- Any contraindication for fMRI
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Interventions
16 hours of fasting
Fed a standardized meal
Neuroimaging with computational modeling
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05995496