RecruitingPhase 3NCT05999630

Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated With Radioactive Iodine for Thyroid Cancer

The Use of Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Who Are Treated With Radioactive Iodine for Thyroid Cancer

Sponsor

Vanderbilt University Medical Center

Enrollment

100 participants

Start Date

Aug 21, 2023

Study Type

INTERVENTIONAL

Conditions

Thyroid Cancer Nasolacrimal Duct Obstruction

Summary

The association of radioiodine therapy for the treatment of thyroid cancer with nasolacrimal duct obstruction has been well documented in the medical literature. Prior case reports have documented radioactive iodine detection in the tears of patients following radioiodine therapy. It is possible that radioactive uptake by the cells in the lacrimal sac and nasolacrimal duct lead to inflammation, fibrosis, and obstruction of the tear duct over time. A recent study has shown that the administration of artificial tears decreases the level of detectable radioiodine in the tears of patients undergoing radioiodine therapy for thyroid cancer. The purpose of this study will be to assess whether administering tears after radioactive iodine therapy for thyroid cancer decreases the incidence of nasolacrimal duct obstruction in the two years following radioactive iodine treatment.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether using artificial tear eye drops after radioactive iodine treatment for thyroid cancer can prevent blockage of the tear ducts — a known side effect of the treatment that can cause constant watering eyes or infections. **You may be eligible if...** - You are 18 years or older - You are being treated for thyroid cancer with radioactive iodine (a dose of 150 mCi or higher) **You may NOT be eligible if...** - You currently use any eye drops other than artificial tears - You have a history of eye or tear duct injury, infections of the tear ducts, or pre-existing blockage - You have previously received radiation to the head or neck area - You are currently on or have received chemotherapy drugs that can affect tear ducts (such as 5-fluorouracil or docetaxel) - You already have a blocked tear duct - You have a condition that increases the risk of tear duct problems (such as sarcoidosis or chronic lymphocytic leukemia) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGArtificial Tears Methylcellulose

Participants will self-administer the artificial tears according to the schedule.

Locations(1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

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NCT05999630

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