Evaluation of the Effect of Liposomal L-Arg and Vit C Integration on Mitochondrial Function in Patients With Heart Failure
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
56 participants
Mar 21, 2023
INTERVENTIONAL
Conditions
Summary
Pilot study to assess the effect of L-Arg and Vit C liposomal supplementation on mitochondrial function in patients with heart failure, through analysis of the viability of mitochondria isolated from peripheral blood of mononucleate cells (PBMC).
Eligibility
Inclusion Criteria2
- Age ≥18 years
- Diagnosis of heart failure with preserved EF 45%.
Exclusion Criteria9
- Age \<18 years
- Left ventricular ejection fraction \<45%
- Valvular heart disease
- Previous myocardial infarction or coronary heart disease
- Hypertension
- Diabetes mellitus
- Intolerance to L-arginine and liposomal vitamin C
- Pregnancy
- Lactation.
Interventions
Once the diagnosis of heart failure is established, patients will be randomized into a double-blind treatment to receive with a 1:1 ratio an oral supplement of 1.66 g L-arginine and 500 mg of liposomal vitamin C once a day (Bioarginine. C , Pharmaceutical Damor) for 3 months (treatment group) or an oral supplement of Placebo once a day for 3 months (control group)
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06044194