RecruitingNot ApplicableNCT06055920

The PEERLESS II Study

PEERLESS II: RCT of FlowTriever vs. Anticoagulation Alone in Pulmonary Embolism

Sponsor

Inari Medical

Enrollment

1,200 participants

Start Date

Nov 17, 2023

Study Type

INTERVENTIONAL

Conditions

Pulmonary Embolism

Summary

This study is a prospective, multicenter, randomized controlled trial of the FlowTriever System plus anticoagulation compared to anticoagulation alone for intermediate-risk acute PE.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Anticoagulation Agents and a medical device called FlowTriever System for people with pulmonary embolism. The study is currently recruiting participants at 83 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEFlowTriever System

Mechanical Thrombectomy for pulmonary embolism

DRUGAnticoagulation Agents

Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc. Anticoagulants are a group of medications that decrease your blood's ability to clot.

Locations(83)

UAB Division of Cardiovascular Disease

Birmingham, Alabama, United States

Brookwood Medical Center

Birmingham, Alabama, United States

Huntington Memorial Hospital

Pasadena, California, United States

University of Colorado, Denver

Aurora, Colorado, United States

Yale University

New Haven, Connecticut, United States

HCA FL Largo Medical Center

Largo, Florida, United States

AdventHealth Orlando

Orlando, Florida, United States

Emory University

Atlanta, Georgia, United States

Northwestern University

Chicago, Illinois, United States

Baptist Health Louisville

Louisville, Kentucky, United States

McLaren Greater Lansing

Lansing, Michigan, United States

Metropolitan Heart & Vascular Institute

Coon Rapids, Minnesota, United States

Mayo Clinic

Rochester, Minnesota, United States

Saint Luke's Hospital of Kansas City

Kansas City, Missouri, United States

Mercy Hospital Springfield

Springfield, Missouri, United States

Nebraska Medical Center

Omaha, Nebraska, United States

Virtua Health

Camden, New Jersey, United States

Valley Health

Ridgewood, New Jersey, United States

SUNY, The University of Buffalo/Gates Vascular

Buffalo, New York, United States

Northwell Health

New York, New York, United States

Jamaica Hospital

Queens, New York, United States

University of Rochester Medical Center

Rochester, New York, United States

Stony Brook University Hospital

Stony Brook, New York, United States

Montefiore Medical Center

The Bronx, New York, United States

University of Cincinnati Medical Center

Cincinnati, Ohio, United States

The Cleveland Clinic Foundation

Cleveland, Ohio, United States

Ohio State University - Wexner Medical Center

Columbus, Ohio, United States

St. Luke's University Hospital

Bethlehem, Pennsylvania, United States

AHN Saint Vincent Hospital

Erie, Pennsylvania, United States

UPMC Hamot

Erie, Pennsylvania, United States

UPMC Harrisburg

Harrisburg, Pennsylvania, United States

The University of Pennsylvania

Philadelphia, Pennsylvania, United States

Thomas Jefferson University

Philadelphia, Pennsylvania, United States

Allegheny Health Network Research Institute

Pittsburgh, Pennsylvania, United States

UPMC Heart and Vascular Institute

Pittsburgh, Pennsylvania, United States

Wellspan York Hospital

York, Pennsylvania, United States

HCA Tristar

Brentwood, Tennessee, United States

UTMC Knoxville

Knoxville, Tennessee, United States

Ascension Saint Thomas Hospital

Nashville, Tennessee, United States

Parkland Hospital

Dallas, Texas, United States

Texas Health Harris Methodist Hospital

Fort Worth, Texas, United States

Methodist Main Hospital

San Antonio, Texas, United States

Baylor Scott & White - Temple

Temple, Texas, United States

Inova Fairfax

Falls Church, Virginia, United States

Sentara Vascular Specialists

Norfolk, Virginia, United States

University of Washington

Seattle, Washington, United States

Providence Sacred Heart

Spokane, Washington, United States

Charleston Area Medical Center

Charleston, West Virginia, United States

West Virginia University Ruby Memorial Hospital

Morgantown, West Virginia, United States

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, United States

Onze Lieve Vrouwziekenhuis

Aalst, Belgium

Royal Columbian Hospital

New Westminster, British Columbia, Canada

Surrey Memorial Hospital

Surrey, British Columbia, Canada

Vancouver General Hospital

Vancouver, British Columbia, Canada

Aarhus University Hospital

Aarhus, Denmark

CHU Lille

Lille, France

Hôpital Louis Pradel

Lyon, France

AP-HM Hopital La Timone

Marseille, France

Hôpital Nord Marseille

Marseille, France

University Hospital Augsburg

Augsburg, Germany

Universitäts-Herzzentrum Bad Krozingen

Bad Krozingen, Germany

Charité Campus Virchow Clinic - Klinik fuer Radiologie

Berlin, Germany

Unfall Krankenhaus Berlin

Berlin, Germany

University Hospital Cologne

Cologne, Germany

HerzZentrum Dresden Universitaetsklinik

Dresden, Germany

Universitaetsklinikum Dὒsseldorf

Düsseldorf, Germany

Elisabeth Hospital GmbH

Essen, Germany

Universitaetsklinikum Essen

Essen, Germany

CCB Frankfurt

Frankfurt, Germany

Universitaetsklinikum Hamburg Eppendorf

Hamburg, Germany

University Hospital - Heidelberg

Heidelberg, Germany

Universitaetsklinikum Saarlandes Homburg

Homburg, Germany

Westpfalz Klinikum

Kaiserslautern, Germany

Klinikum rechts der Isar (TUM)

Munich, Germany

Ludwig Maximilians-University

Munich, Germany

University Hospital Regensburg

Regensburg, Germany

Helios Kliniken Schwerin

Schwerin, Germany

Schwarzwald-Baar-Klinikum

Villingen-Schwenningen, Germany

John Paul II Hospital

Krakow, Poland

Hopital Clinico Universitario San Carlos

Madrid, Spain

Universitaetsspital Basel

Basel, Switzerland

Universitätsspital Bern

Bern, Switzerland

Luzerner Kantonsspital

Lucerne, Switzerland

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NCT06055920

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